5TQ8
Design and Synthesis of a pan-JAK Kinase Inhibitor Clinical Candidate (PF-06263276) Suitable for Inhaled and Topical Delivery for the Treatment of Inflammatory Diseases of the Lungs and Skin
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Tyrosine-protein kinase JAK2 | polymer | 298 | 34873.7 | 1 | UniProt (O60674) Pfam (PF07714) | Homo sapiens (Human) | Janus kinase 2,JAK-2 |
| 2 | B (A) | {2-[6-(2-ethyl-5-fluoro-4-hydroxyphenyl)-2H-indazol-3-yl]-3,4,6,7-tetrahydro-5H-imidazo[4,5-c]pyridin-5-yl}[5-(piperidin-1-yl)pyrazin-2-yl]methanone | non-polymer | 566.6 | 1 | Chemie (7GS) | |||
| 3 | C (A) | water | water | 18.0 | 234 | Chemie (HOH) |
Sequence modifications
A: 837 - 1132 (UniProt: O60674)
| PDB | External Database | Details |
|---|---|---|
| Gly 835 | - | expression tag |
| Ser 836 | - | expression tag |
| Ser 1073 | Met 1073 | engineered mutation |
| Thr 1076 | Phe 1076 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 34873.7 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 566.6 | |
| All* | Total formula weight | 35440.4 |
