5TPG

Optimization of spirocyclic proline tryptophanhydroxylase-1 inhibitors

Summary for 5TPG

Entry DOI	10.2210/pdb5tpg/pdb
Related	5L01
Descriptor	Tryptophan 5-hydroxylase 1, FE (III) ION, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... (6 entities in total)
Functional Keywords	tph1, iron, acyl, quanidine, oxidoreductase-inhibitor complex, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	36371.50
Authors	Stein, A.J.,Goldberg, D.R.,De Lombaert, S.,Holt, M.C. (deposition date: 2016-10-20, release date: 2017-01-25, Last modification date: 2024-03-06)
Primary citation	Goldberg, D.R.,De Lombaert, S.,Aiello, R.,Bourassa, P.,Barucci, N.,Zhang, Q.,Paralkar, V.,Stein, A.J.,Holt, M.,Valentine, J.,Zavadoski, W. Optimization of spirocyclic proline tryptophan hydroxylase-1 inhibitors. Bioorg. Med. Chem. Lett., 27:413-419, 2017 Cited by PubMed: 28041831 DOI: 10.1016/j.bmcl.2016.12.053 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.5 Å)

Structure validation