5TPB
Binding domain of BoNT/A complexed with ganglioside variant
Summary for 5TPB
Entry DOI | 10.2210/pdb5tpb/pdb |
Related | 2VU9 |
Descriptor | Botulinum neurotoxin type A, beta-D-galactopyranose-(1-3)-2-acetamido-2-deoxy-beta-D-galactopyranose, N-acetyl-alpha-neuraminic acid, ... (4 entities in total) |
Functional Keywords | binding domain, lectin, ganglioside binding, hydrolase |
Biological source | Clostridium botulinum |
Cellular location | Botulinum neurotoxin A light chain: Secreted. Botulinum neurotoxin A heavy chain: Secreted: P10845 |
Total number of polymer chains | 2 |
Total formula weight | 104119.42 |
Authors | Berntsson, R.P.-A.,Svensson, L.M.,Stenmark, P. (deposition date: 2016-10-20, release date: 2017-01-18, Last modification date: 2024-05-08) |
Primary citation | Hamark, C.,Berntsson, R.P.,Masuyer, G.,Henriksson, L.M.,Gustafsson, R.,Stenmark, P.,Widmalm, G. Glycans Confer Specificity to the Recognition of Ganglioside Receptors by Botulinum Neurotoxin A. J. Am. Chem. Soc., 139:218-230, 2017 Cited by PubMed: 27958736DOI: 10.1021/jacs.6b09534 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.6 Å) |
Structure validation
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