5TLR

Solution NMR structure of gHwTx-IV

5TLR の概要

• エントリーDOI: 10.2210/pdb5tlr/pdb
• NMR情報: BMRB: 30190
• 分子名称: Mu-theraphotoxin-Hs2a (1 entity in total)
• 機能のキーワード: spider toxin, disulfide-rich, sodium channel inhibitor, toxin
• 由来する生物種: Haplopelma schmidti (Chinese bird spider)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 4036.82

構造登録者

Agwa, A.J.,Schroeder, C.I. (登録日: 2016-10-11, 公開日: 2017-02-22, 最終更新日: 2023-06-14)

• 主引用文献: Agwa, A.J.,Lawrence, N.,Deplazes, E.,Cheneval, O.,Chen, R.M.,Craik, D.J.,Schroeder, C.I.,Henriques, S.T.; Spider peptide toxin HwTx-IV engineered to bind to lipid membranes has an increased inhibitory potency at human voltage-gated sodium channel hNaV1.7.; Biochim. Biophys. Acta, 1859:835-844, 2017; PubMed: 28115115; DOI: 10.1016/j.bbamem.2017.01.020

実験手法

SOLUTION NMR