5TJD

Computer-based rational design of improved functionality for antibody catalysts toward organophosphorus compounds

Summary for 5TJD

• Entry DOI: 10.2210/pdb5tjd/pdb
• Descriptor: FAB A.17 L47K mutant HEAVY CHAIN, FAB A.17 L47K mutant Light Chain (3 entities in total)
• Functional Keywords: antibody, rational design, immune system
• Biological source: Homo sapiens (HUMAN); More
• Total number of polymer chains: 2
• Total formula weight: 51369.79

Authors

Chatziefthimiou, S.,Stepanova, A.,Smirnov, I.,Gabibov, A.,Wilmanns, M. (deposition date: 2016-10-04, release date: 2018-05-02, Last modification date: 2024-01-17)

• Primary citation: Mokrushina, Y.A.,Golovin, A.V.,Smirnov, I.V.,Chatziefthimiou, S.D.,Stepanova, A.V.,Bobik, T.V.,Zalevsky, A.O.,Zlobin, A.S.,Konovalov, K.A.,Terekhov, S.S.,Stepanov, A.V.,Pipiya, S.O.,Shamborant, O.G.,Round, E.,Belogurov Jr., A.A.,Bourenkov, G.,Makarov, A.A.,Wilmanns, M.,Xie, J.,Blackburn, G.M.,Gabibov, A.G.,Lerner, R.A.; Multiscale computation delivers organophosphorus reactivity and stereoselectivity to immunoglobulin scavengers.; Proc.Natl.Acad.Sci.USA, 2020; PubMed: 32859757; DOI: 10.1073/pnas.2010317117

Experimental method

X-RAY DIFFRACTION (2.1 Å)