5TIN

Crystal Structure of Human Glycine Receptor alpha-3 Mutant N38Q Bound to AM-3607

Summary for 5TIN

• Entry DOI: 10.2210/pdb5tin/pdb
• Related: 5TIO
• Descriptor: Glycine receptor subunit alpha-3, (3S,3aS,9bS)-2-[(2H-1,3-benzodioxol-5-yl)sulfonyl]-3,5-dimethyl-1,2,3,3a,5,9b-hexahydro-4H-pyrrolo[3,4-c][1,6]naphthyridin-4-one, GLYCINE, ... (6 entities in total)
• Functional Keywords: ligand-gated ion channel neurotransmitter receptor membrane protein cys-loop receptor, transport protein
• Biological source: Homo sapiens (Human); More
• Cellular location: Cell junction, synapse, postsynaptic cell membrane ; Multi-pass membrane protein : O75311
• Total number of polymer chains: 5
• Total formula weight: 212102.14

Authors

Shaffer, P.L.,Huang, X.,Chen, H. (deposition date: 2016-10-03, release date: 2017-01-18, Last modification date: 2023-10-04)

• Primary citation: Huang, X.,Shaffer, P.L.,Ayube, S.,Bregman, H.,Chen, H.,Lehto, S.G.,Luther, J.A.,Matson, D.J.,McDonough, S.I.,Michelsen, K.,Plant, M.M.,Schneider, S.,Simard, J.R.,Teffera, Y.,Yi, S.,Zhang, M.,DiMauro, E.F.,Gingras, J.; Crystal Structures of Human GlyRa3 Bound to a Novel Class of Potentiators with Efficacy in a Mouse Model of Neuropathic Pain; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.61 Å)