5THG

Engineered variant of I-OnuI meganuclease targeting the HIV CCR5 gene; harbors 43 point mutations relative to wild-type I-OnuI

5THG の概要

• エントリーDOI: 10.2210/pdb5thg/pdb
• 分子名称: I-OnuI_e-hCCR5, DNA (29-MER), CALCIUM ION, ... (6 entities in total)
• 機能のキーワード: meganuclease, engineered protein, dna complex, hydrolase-dna complex, hydrolase/dna
• 由来する生物種: synthetic construct; 詳細
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 106294.69

構造登録者

Hallinan, J.P.,Stoddard, B.L. (登録日: 2016-09-29, 公開日: 2017-05-03, 最終更新日: 2024-03-06)

• 主引用文献: Werther, R.,Hallinan, J.P.,Lambert, A.,Haven, K.,Jarjor, J.,Stoddard, B.L.; The structural basis of altered gene specificity resulting from meganuclease and MegaTAL engineering; to be published,

実験手法

X-RAY DIFFRACTION (3.106 Å)