5TH4

Crystal Structure of 1-hydroxypyridine-2(1H)-thione bound to human carbonic anhydrase 2 L198G

Summary for 5TH4

Entry DOI	10.2210/pdb5th4/pdb
Related	5THI 5THJ 5THN 5TI0
Descriptor	Carbonic anhydrase 2, ZINC ION, 1-hydroxy-2-sulfanylpyridinium, ... (6 entities in total)
Functional Keywords	inhibitor, carbonic anhydrase 2, complex, metalloenzyme inhibitor, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29596.76
Authors	Dick, B.,Cohen, S. (deposition date: 2016-09-29, release date: 2017-04-26, Last modification date: 2023-10-04)
Primary citation	Dick, B.L.,Patel, A.,McCammon, J.A.,Cohen, S.M. Effect of donor atom identity on metal-binding pharmacophore coordination. J. Biol. Inorg. Chem., 22:605-613, 2017 Cited by PubMed: 28389830 DOI: 10.1007/s00775-017-1454-3 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.47 Å)

Structure validation