5TGK

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dATP

5TGK の概要

• エントリーDOI: 10.2210/pdb5tgk/pdb
• 関連するPDBエントリー: 5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFE 5TFF 5TFG 5TFH 5TFI 5TFJ
• 分子名称: Cystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, ... (4 entities in total)
• 機能のキーワード: hnbd1, cftr, abc transport, datp, hydrolase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 26040.90

構造登録者

Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F. (登録日: 2016-09-28, 公開日: 2018-05-09, 最終更新日: 2023-10-04)

• 主引用文献: Wang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.A.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F.; Ligand binding to a remote site thermodynamically corrects the F508del mutation in the human cystic fibrosis transmembrane conductance regulator.; J. Biol. Chem., 2018; PubMed: 29903914; DOI: 10.1074/jbc.RA117.000819

実験手法

X-RAY DIFFRACTION (1.912 Å)