5TFO

CRYSTAL STRUCTURE OF THE ZIKA VIRUS NS2B-NS3 PROTEASE with a deletion V76-L86 in NS2b

5TFO の概要

• エントリーDOI: 10.2210/pdb5tfo/pdb
• 関連するPDBエントリー: 5tfn
• 分子名称: NS2B-NS3 Protease CHIMERA,NS2B-NS3 PROTEASE,NS2B-NS3 Protease CHIMERA (2 entities in total)
• 機能のキーワード: flavivirus, serine protease, zika virus, viral protein
• 由来する生物種: Zika virus (ZIKV); 詳細
• 細胞内の位置: Capsid protein C: Virion . Peptide pr: Secreted . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane; Peripheral membrane protein; Cytoplasmic side: Q32ZE1
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 49016.64

構造登録者

Aleshin, A.E.,Bankston, L.,Liddington, R.C. (登録日: 2016-09-26, 公開日: 2017-10-25, 最終更新日: 2024-10-16)

• 主引用文献: Aleshin, A.E.,Bankston, L.,Shiryaev, S.A.,Terskikh, A.,Strongin, A.,Liddington, R.C.; A novel conformation for the Zika virus NS2B-NS3 protease offers new insights into biological regulation and inhibitor design.; To Be Published,

実験手法

X-RAY DIFFRACTION (2.51 Å)