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5TFJ

Nucleotide-binding domain 1 of the human cystic fibrosis transmembrane conductance regulator (CFTR) with dCTP

Summary for 5TFJ
Entry DOI10.2210/pdb5tfj/pdb
Related5TF7 5TF8 5TFA 5TFB 5TFC 5TFD 5TFE 5TFF 5TFG 5TFH 5TFI 5TGK
DescriptorCystic fibrosis transmembrane conductance regulator, MAGNESIUM ION, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, ... (4 entities in total)
Functional Keywordshnbd1, cftr, abc transport, atp, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight26016.87
Authors
Primary citationWang, C.,Aleksandrov, A.A.,Yang, Z.,Forouhar, F.,Proctor, E.,Kota, P.,An, J.,Kaplan, A.,Khazanov, N.,Boel, G.,Stockwell, B.R.,Senderowitz, H.,Dokholyan, N.V.,Riordan, J.R.,Brouillette, C.G.,Hunt, J.F.
Thermodynamic correction of F508del-CFTR by ligand binding to a remote site in the mutated domain
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

數據於2024-03-27公開中

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