5TF5

CRYSTAL STRUCTURE OF HUMAN KAT-2 IN COMPLEX WITH A REVERSIBLE INHIBITOR

5TF5 の概要

• エントリーDOI: 10.2210/pdb5tf5/pdb
• 分子名称: Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial, (2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid (3 entities in total)
• 機能のキーワード: ns-1502, reversible kat-2 inhibitor, llp, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Mitochondrion : Q8N5Z0
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95621.28

構造登録者

Nematollahi, A.,Sun, G.,Church, W.B. (登録日: 2016-09-24, 公開日: 2016-10-05, 最終更新日: 2023-11-15)

• 主引用文献: Nematollahi, A.,Sun, G.,Jayawickrama, G.,Hanrahan, J.R.,Church, W.B.; Crystal structure and mechanistic analysis of a novel human kynurenine aminotransferase-2 reversible inhibitor; Med.Chem.Res., 2017; DOI: 10.1007/s00044-017-1950-6

実験手法

X-RAY DIFFRACTION (1.807 Å)