5TEG

Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine

Summary for 5TEG

Entry DOI	10.2210/pdb5teg/pdb
Descriptor	N-lysine methyltransferase KMT5A, Histone H4 mutant peptide with H4K20norleucine, S-ADENOSYLMETHIONINE, ... (4 entities in total)
Functional Keywords	transferase, histone h4, norleucine
Biological source	Homo sapiens (Human) More
Cellular location	Nucleus: Q9NQR1
Total number of polymer chains	4
Total formula weight	39388.70
Authors	Judge, R.A.,Petros, A.M. (deposition date: 2016-09-21, release date: 2016-12-07, Last modification date: 2023-11-15)
Primary citation	Judge, R.A.,Zhu, H.,Upadhyay, A.K.,Bodelle, P.M.,Hutchins, C.W.,Torrent, M.,Marin, V.L.,Yu, W.,Vedadi, M.,Li, F.,Brown, P.J.,Pappano, W.N.,Sun, C.,Petros, A.M. Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8. ACS Med Chem Lett, 7:1102-1106, 2016 Cited by PubMed: 27994746 DOI: 10.1021/acsmedchemlett.6b00303 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation