5TEG

Crystal structure of hSETD8 in complex with histone H4K20 norleucine mutant peptide and S-Adenosylmethionine

5TEG の概要

• エントリーDOI: 10.2210/pdb5teg/pdb
• 分子名称: N-lysine methyltransferase KMT5A, Histone H4 mutant peptide with H4K20norleucine, S-ADENOSYLMETHIONINE, ... (4 entities in total)
• 機能のキーワード: transferase, histone h4, norleucine
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Nucleus: Q9NQR1
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 39388.70

構造登録者

Judge, R.A.,Petros, A.M. (登録日: 2016-09-21, 公開日: 2016-12-07, 最終更新日: 2023-11-15)

• 主引用文献: Judge, R.A.,Zhu, H.,Upadhyay, A.K.,Bodelle, P.M.,Hutchins, C.W.,Torrent, M.,Marin, V.L.,Yu, W.,Vedadi, M.,Li, F.,Brown, P.J.,Pappano, W.N.,Sun, C.,Petros, A.M.; Turning a Substrate Peptide into a Potent Inhibitor for the Histone Methyltransferase SETD8.; ACS Med Chem Lett, 7:1102-1106, 2016; PubMed: 27994746; DOI: 10.1021/acsmedchemlett.6b00303

実験手法

X-RAY DIFFRACTION (1.3 Å)