5TCO
Human p38 MAP Kinase in Complex with Dibenzosuberone Compound 1
Summary for 5TCO
Entry DOI | 10.2210/pdb5tco/pdb |
Related | 5TBE |
Descriptor | Mitogen-activated protein kinase 14, 3-[(3-benzamido-4-fluoranyl-phenyl)amino]-~{N}-(2-morpholin-4-ylethyl)-11-oxidanylidene-5,6-dihydrodibenzo[1,2-~{d}:1',2'-~{f}][7]annulene-9-carboxamide, octyl beta-D-glucopyranoside, ... (4 entities in total) |
Functional Keywords | inhibitor, dibenzosuberone, human p38 map kinase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 42446.45 |
Authors | Mayer-Wrangowski, S.C.,Rauh, D. (deposition date: 2016-09-15, release date: 2017-04-19, Last modification date: 2024-05-08) |
Primary citation | Wentsch, H.K.,Walter, N.M.,Buhrmann, M.,Mayer-Wrangowski, S.,Rauh, D.,Zaman, G.J.R.,Willemsen-Seegers, N.,Buijsman, R.C.,Henning, M.,Dauch, D.,Zender, L.,Laufer, S. Optimized Target Residence Time: Type I1/2 Inhibitors for p38 alpha MAP Kinase with Improved Binding Kinetics through Direct Interaction with the R-Spine. Angew. Chem. Int. Ed. Engl., 56:5363-5367, 2017 Cited by PubMed: 28397331DOI: 10.1002/anie.201701185 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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