5TCM

First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536

Summary for 5TCM

• Entry DOI: 10.2210/pdb5tcm/pdb
• Related: 5TCK
• Descriptor: Uncharacterized protein, 4-{[(7R)-8-cyclopentyl-7-ethyl-5-methyl-6-oxo-5,6,7,8-tetrahydropteridin-2-yl]amino}-3-methoxy-N-(1-methylpiperidin-4-yl)benzamide, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: bromodomain, inhibitor, structural genomics consortium (sgc), unknown function
• Biological source: Leishmania donovani (strain BPK282A1)
• Total number of polymer chains: 3
• Total formula weight: 45716.94

Authors

Lin, Y.H.,Hou, C.F.D.,Loppnau, P.,Dong, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Hui, R.,Walker, J.R.,Structural Genomics Consortium (SGC) (deposition date: 2016-09-15, release date: 2016-10-05, Last modification date: 2023-10-04)

• Primary citation: Lin, Y.H.,Hou, C.F.D.,Loppnau, P.,Dong, A.,Bountra, C.,Edwards, A.M.,Arrowsmith, C.H.,Hui, R.,Walker, J.R.,Structural Genomics Consortium (SGC); First Bromodomain from Leishmania donovani LdBPK.091320 complexed with BI-2536; To be published,

Experimental method

X-RAY DIFFRACTION (2.2 Å)