5TCF
Crystal structure of tryptophan synthase from M. tuberculosis - ligand-free form
Summary for 5TCF
Entry DOI | 10.2210/pdb5tcf/pdb |
Related | 5TCG 5TCH 5TCI 5TCJ |
Descriptor | Tryptophan synthase alpha chain, Tryptophan synthase beta chain, MALONATE ION, ... (6 entities in total) |
Functional Keywords | plp, heterotetramer, amino acid biosynthesis, substrate channeling, allostery, structural genomics, center for structural genomics of infectious diseases, csgid, lyase |
Biological source | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) More |
Total number of polymer chains | 8 |
Total formula weight | 290060.64 |
Authors | Michalska, K.,Maltseva, N.,Jedrzejczak, R.,Joachimiak, A.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2016-09-15, release date: 2017-05-31, Last modification date: 2023-11-15) |
Primary citation | Wellington, S.,Nag, P.P.,Michalska, K.,Johnston, S.E.,Jedrzejczak, R.P.,Kaushik, V.K.,Clatworthy, A.E.,Siddiqi, N.,McCarren, P.,Bajrami, B.,Maltseva, N.I.,Combs, S.,Fisher, S.L.,Joachimiak, A.,Schreiber, S.L.,Hung, D.T. A small-molecule allosteric inhibitor of Mycobacterium tuberculosis tryptophan synthase. Nat. Chem. Biol., 13:943-950, 2017 Cited by PubMed: 28671682DOI: 10.1038/nchembio.2420 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.46 Å) |
Structure validation
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