5TBP

Crystal Structure of RXR-alpha ligand binding domain complexed with synthetic modulator K8003

5TBP の概要

• エントリーDOI: 10.2210/pdb5tbp/pdb
• 分子名称: Retinoic acid receptor RXR-alpha, [(1Z)-5-fluoro-2-methyl-1-{[4-(propan-2-yl)phenyl]methylidene}-1H-inden-3-yl]acetic acid, ACETATE ION, ... (6 entities in total)
• 機能のキーワード: nuclear receptor, sulindac, akt activation, complex, tetramer, transcription, rxr, lbd
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 111772.08

構造登録者

Aleshin, A.E.,Liddington, R.C.,Su, Y.,Zhang, X. (登録日: 2016-09-12, 公開日: 2017-08-09, 最終更新日: 2023-10-04)

• 主引用文献: Chen, L.,Aleshin, A.E.,Alitongbieke, G.,Zhou, Y.,Zhang, X.,Ye, X.,Hu, M.,Ren, G.,Chen, Z.,Ma, Y.,Zhang, D.,Liu, S.,Gao, W.,Cai, L.,Wu, L.,Zeng, Z.,Jiang, F.,Liu, J.,Zhou, H.,Cadwell, G.,Liddington, R.C.,Su, Y.,Zhang, X.K.; Modulation of nongenomic activation of PI3K signalling by tetramerization of N-terminally-cleaved RXR alpha.; Nat Commun, 8:16066-16066, 2017; PubMed: 28714476; DOI: 10.1038/ncomms16066

実験手法

X-RAY DIFFRACTION (2.6 Å)