5T4V

Crystal structure of the bromodomain of human BRPF1 in complex with NI-48 ligand

5T4V の概要

• エントリーDOI: 10.2210/pdb5t4v/pdb
• 分子名称: Peregrin, 4-cyano-N-(7-methoxy-1,4-dimethyl-2-oxo-1,2-dihydroquinolin-6-yl)benzene-1-sulfonamide, 1,2-ETHANEDIOL, ... (5 entities in total)
• 機能のキーワード: transcription, structural genomics, structural genomics consortium, sgc
• 由来する生物種: Homo sapiens (Human)
• 細胞内の位置: Nucleus : P55201
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 14195.21

構造登録者

Tallant, C.,Igoe, N.,Bayle, E.D.,Nunez-Alonso, G.,Newman, J.A.,Mathea, S.,Savitsky, P.,Fedorov, O.,Brennan, P.E.,Muller, S.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Fish, P.,Knapp, S.,Structural Genomics Consortium (SGC) (登録日: 2016-08-30, 公開日: 2017-02-08, 最終更新日: 2024-01-17)

• 主引用文献: Igoe, N.,Bayle, E.D.,Fedorov, O.,Tallant, C.,Savitsky, P.,Rogers, C.,Owen, D.R.,Deb, G.,Somervaille, T.C.,Andrews, D.M.,Jones, N.,Cheasty, A.,Ryder, H.,Brennan, P.E.,Muller, S.,Knapp, S.,Fish, P.V.; Design of a Biased Potent Small Molecule Inhibitor of the Bromodomain and PHD Finger-Containing (BRPF) Proteins Suitable for Cellular and in Vivo Studies.; J. Med. Chem., 60:668-680, 2017; PubMed: 28068087; DOI: 10.1021/acs.jmedchem.6b01583

実験手法

X-RAY DIFFRACTION (1.65 Å)