5T2Z
Crystal Structure of Multi-drug Resistant HIV-1 Protease PR-S17 in Complex with Darunavir
Summary for 5T2Z
Entry DOI | 10.2210/pdb5t2z/pdb |
Related | 5T2E |
Descriptor | Protease, (3R,3AS,6AR)-HEXAHYDROFURO[2,3-B]FURAN-3-YL(1S,2R)-3-[[(4-AMINOPHENYL)SULFONYL](ISOBUTYL)AMINO]-1-BENZYL-2-HYDROXYPROPYLCARBAMATE (3 entities in total) |
Functional Keywords | protease, hydrolase, inhibitor, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 2 |
Total formula weight | 22130.85 |
Authors | Agniswamy, J.,Weber, I.T. (deposition date: 2016-08-24, release date: 2017-01-11, Last modification date: 2023-10-04) |
Primary citation | Agniswamy, J.,Louis, J.M.,Roche, J.,Harrison, R.W.,Weber, I.T. Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics. PLoS ONE, 11:e0168616-e0168616, 2016 Cited by PubMed: 27992544DOI: 10.1371/journal.pone.0168616 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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