5T2Y

Crystal Structure of C. jejuni PglD in complex with 5-methyl-4-(methylamino)-2-phenethylthieno[2,3-d]pyrimidine-6-carboxylic acid

5T2Y の概要

• エントリーDOI: 10.2210/pdb5t2y/pdb
• 関連するPDBエントリー: 3BSS 3BSY
• 分子名称: UDP-N-acetylbacillosamine N-acetyltransferase, 5-methyl-4-(methylamino)-2-(2-phenylethyl)thieno[2,3-d]pyrimidine-6-carboxylic acid, GLYCEROL, ... (5 entities in total)
• 機能のキーワード: campylobacter jejuni bacterial acetyltransferase inhibitor complex, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Campylobacter jejuni subsp. jejuni serotype O:2 (strain ATCC 700819 / NCTC 11168)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 43867.26

構造登録者

De Schutter, J.W.,Imperiali, B. (登録日: 2016-08-24, 公開日: 2017-02-22, 最終更新日: 2024-03-06)

• 主引用文献: De Schutter, J.W.,Morrison, J.P.,Morrison, M.J.,Ciulli, A.,Imperiali, B.; Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni.; J. Med. Chem., 60:2099-2118, 2017; PubMed: 28182413; DOI: 10.1021/acs.jmedchem.6b01869

実験手法

X-RAY DIFFRACTION (1.94 Å)