5T1V

Crystal structure of Zika virus NS2B-NS3 protease in apo-form.

Summary for 5T1V

• Entry DOI: 10.2210/pdb5t1v/pdb
• Descriptor: NS2B-NS3 protease,NS2B-NS3 protease (1 entity in total)
• Functional Keywords: hydrolase, peptidase s7, flavivirus ns3 serine protease., structural genomics, center for structural genomics of infectious diseases, csgid
• Biological source: Zika virus (ZIKV); More
• Cellular location: Protein C: Virion . Small envelope protein M: Virion membrane ; Multi-pass membrane protein . Envelope protein E: Virion membrane ; Multi-pass membrane protein . Non-structural protein 1: Secreted . Non-structural protein 2A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease subunit NS2B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Serine protease NS3: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side . Non-structural protein 4A: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . Non-structural protein 4B: Host endoplasmic reticulum membrane ; Multi-pass membrane protein . RNA-directed RNA polymerase NS5: Host endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : Q32ZE1
• Total number of polymer chains: 2
• Total formula weight: 58145.50

Authors

Nocadello, S.,Light, S.H.,Minasov, G.,Shuvalova, L.,Cardona-Correa, A.A.,Ojeda, I.,Vargas, J.,Johnson, M.E.,Lee, H.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID) (deposition date: 2016-08-22, release date: 2016-09-07, Last modification date: 2025-10-22)

• Primary citation: Nocadello, S.,Light, S.H.,Minasov, G.,Shuvalova, L.A.,Cardona-Correa, A.A.,Ojeda, I.,Vargas, J.,Johnson, M.E.,Lee, H.,Anderson, W.F.,Center for Structural Genomics of Infectious Diseases (CSGID); Crystal structure of Zika virus NS2B-NS3 protease in apo-form.; To Be Published,

Experimental method

X-RAY DIFFRACTION (3.1 Å)