5T19

Structure of PTP1B complexed with N-(3'-(1,1-dioxido-4-oxo-1,2,5-thiadiazolidin-2-yl)-4'-methyl-[1,1'-biphenyl]-4-yl)acetamide

Summary for 5T19

• Entry DOI: 10.2210/pdb5t19/pdb
• Descriptor: Tyrosine-protein phosphatase non-receptor type 1, MAGNESIUM ION, 5-[4-methyl-4'-(methylamino)[1,1'-biphenyl]-3-yl]-1lambda~6~,2,5-thiadiazolidine-1,1,3-trione, ... (5 entities in total)
• Functional Keywords: hydrolase, protein tyrosine phosphatase, 5-(aryl)-1, 2, 5-thiadiazolidin-3-one-1, 1-dioxide unit
• Biological source: Homo sapiens (Human)
• Cellular location: Endoplasmic reticulum membrane ; Peripheral membrane protein ; Cytoplasmic side : P18031
• Total number of polymer chains: 1
• Total formula weight: 38022.89

Authors

Laciak, A.R.,Tanner, J.J. (deposition date: 2016-08-18, release date: 2017-04-12, Last modification date: 2023-10-04)

• Primary citation: Punthasee, P.,Laciak, A.R.,Cummings, A.H.,Ruddraraju, K.V.,Lewis, S.M.,Hillebrand, R.,Singh, H.,Tanner, J.J.,Gates, K.S.; Covalent Allosteric Inactivation of Protein Tyrosine Phosphatase 1B (PTP1B) by an Inhibitor-Electrophile Conjugate.; Biochemistry, 56:2051-2060, 2017; PubMed: 28345882; DOI: 10.1021/acs.biochem.7b00151

Experimental method

X-RAY DIFFRACTION (2.1001 Å)