5SXN

Structure-based design of a new series of N-piperidin-3-ylpyrimidine-5-carboxamides as renin inhibitors

Summary for 5SXN

Entry DOI	10.2210/pdb5sxn/pdb
Related	5SY2 5SY3 5SZ9
Descriptor	Renin, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-[(furan-2-yl)methyl]-2-phenylquinazolin-4-amine, ... (7 entities in total)
Functional Keywords	protein-ligand complex, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Homo sapiens (Human)
Cellular location	Secreted: P00797
Total number of polymer chains	2
Total formula weight	75617.07
Authors	Snell, G.P.,Behnke, C.A.,Okada, K.,Hideyuki, O.,Sang, B.-C.,Lane, W. (deposition date: 2016-08-09, release date: 2016-11-02, Last modification date: 2020-07-29)
Primary citation	Imaeda, Y.,Tawada, M.,Suzuki, S.,Tomimoto, M.,Kondo, M.,Tarui, N.,Sanada, T.,Kanagawa, R.,Snell, G.,Behnke, C.A.,Kubo, K.,Kuroita, T. Structure-based design of a new series of N-(piperidin-3-yl)pyrimidine-5-carboxamides as renin inhibitors. Bioorg.Med.Chem., 24:5771-5780, 2016 Cited by PubMed: 27687967 DOI: 10.1016/j.bmc.2016.09.030 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.1 Å)

Structure validation