5SWQ

Crystal Structure of HLA-A*0201 in complex with NA231, an influenza epitope

5SWQ の概要

• エントリーDOI: 10.2210/pdb5swq/pdb
• 分子名称: HLA class I histocompatibility antigen, A-2 alpha chain, Beta-2-microglobulin, NA231 influenza epitope, ... (4 entities in total)
• 機能のキーワード: hla-a*02:01, cross-reactivity, heterologous immunity, tcr, t cell, immune system
• 由来する生物種: Homo sapiens (Human); 詳細
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P01892; Secreted . Note=(Microbial infection) In the presence of M: P61769
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 44656.60

構造登録者

Josephs, T.M.,Rossjohn, J.,Gras, S. (登録日: 2016-08-08, 公開日: 2016-10-05, 最終更新日: 2023-10-04)

• 主引用文献: Grant, E.J.,Josephs, T.M.,Valkenburg, S.A.,Wooldridge, L.,Hellard, M.,Rossjohn, J.,Bharadwaj, M.,Kedzierska, K.,Gras, S.; Lack of Heterologous Cross-reactivity toward HLA-A*02:01 Restricted Viral Epitopes Is Underpinned by Distinct alpha beta T Cell Receptor Signatures.; J.Biol.Chem., 291:24335-24351, 2016; PubMed: 27645996; DOI: 10.1074/jbc.M116.753988

実験手法

X-RAY DIFFRACTION (2 Å)