5SWH

c-Src V281C kinase domain in complex with Rao-IV-151

5SWH の概要

• エントリーDOI: 10.2210/pdb5swh/pdb
• 分子名称: Proto-oncogene tyrosine-protein kinase Src, (2R)-3-[4-amino-5-(4-chlorophenyl)-7-(2-methoxyethyl)-7H-pyrrolo[2,3-d]pyrimidin-6-yl]-2-cyano-N-(propan-2-yl)propanami de (3 entities in total)
• 機能のキーワード: active conformation, covalently-linked inihibitor, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• 由来する生物種: Gallus gallus (Chicken)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 66343.16

構造登録者

Merritt, E.A.,Dieter, E.M. (登録日: 2016-08-08, 公開日: 2017-08-16, 最終更新日: 2023-10-04)

• 主引用文献: Register, A.C.,Maly, D.J.; A combined approach reveals a regulatory mechanism coupling Src's kinase activity, localization, and phosphotransferase-independent functions; Mol.Cell, 2019

実験手法

X-RAY DIFFRACTION (2.5 Å)