5SK3

Crystal Structure of human phosphodiesterase 10 in complex with [2-cyclopropyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]imidazo[1,2-b]pyridazin-3-yl]methanol

Summary for 5SK3

• Entry DOI: 10.2210/pdb5sk3/pdb
• Group deposition: To be published (G_1002229)
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, {(4S)-2-cyclopropyl-6-[(1-methyl-4-phenyl-1H-imidazol-2-yl)ethynyl]imidazo[1,2-b]pyridazin-3-yl}methanol, ZINC ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 159489.34

Authors

Joseph, C.,Benz, J.,Flohr, A.,Groebke-Zbinden, K.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-04-03)

• Primary citation: Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.32 Å)