5SJ4
Crystal Structure of human phosphodiesterase 10 in complex with 1-methyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]-5H-pyrazolo[3,4-d]pyrimidin-4-one
Summary for 5SJ4
Entry DOI | 10.2210/pdb5sj4/pdb |
Group deposition | To be published (G_1002229) |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 159365.30 |
Authors | Joseph, C.,Benz, J.,Flohr, A.,Groebke-Zbinden, K.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-04-03) |
Primary citation | Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a human phosphodiesterase 10 complex To be published, |
Experimental method | X-RAY DIFFRACTION (2.77 Å) |
Structure validation
Download full validation report