5SHI
Crystal Structure of human phosphodiesterase 10 in complex with 2,3,5-trimethyl-6-[2-(1-methyl-4-phenylimidazol-2-yl)ethyl]imidazo[1,2-a]pyridine
Summary for 5SHI
Entry DOI | 10.2210/pdb5shi/pdb |
Group deposition | To be published (G_1002229) |
Descriptor | cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, (4R)-2,3,5-trimethyl-6-[2-(1-methyl-4-phenyl-1H-imidazol-2-yl)ethyl]imidazo[1,2-a]pyridine, ZINC ION, ... (5 entities in total) |
Functional Keywords | phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 4 |
Total formula weight | 159389.48 |
Authors | Joseph, C.,Benz, J.,Flohr, A.,Groebke-Zbinden, K.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-04-03) |
Primary citation | Flohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G. Crystal Structure of a human phosphodiesterase 10 complex To be published, |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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