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5SGO

Crystal Structure of human phosphodiesterase 10 in complex with N-[3-[3-[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxypropoxy]phenyl]acetamide

Summary for 5SGO
Entry DOI10.2210/pdb5sgo/pdb
Group depositionTo be published (G_1002229)
DescriptorcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, N-[3-(3-{[5-(4-fluorophenyl)thieno[2,3-d]pyrimidin-4-yl]oxy}propoxy)phenyl]acetamide, ... (5 entities in total)
Functional Keywordsphosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological sourceHomo sapiens (human)
Total number of polymer chains4
Total formula weight159438.06
Authors
Joseph, C.,Benz, J.,Flohr, A.,Leal, L.,Rudolph, M.G. (deposition date: 2022-02-01, release date: 2022-10-12, Last modification date: 2024-04-03)
Primary citationFlohr, A.,Schlatter, D.,Kuhn, B.,Rudolph, M.G.
Crystal Structure of a human phosphodiesterase 10 complex
To be published,
Experimental method
X-RAY DIFFRACTION (2.3 Å)
Structure validation

221051

건을2024-06-12부터공개중

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