5SFE

CRYSTAL STRUCTURE OF HUMAN PHOSPHODIESTERASE 10 IN COMPLEX WITH c2(nc1nc(cn1cc2)c3cc(ccc3)F)NC(c4c(cnn4C)C(N(C)C)=O)=O, micromolar IC50=0.011191

Summary for 5SFE

• Entry DOI: 10.2210/pdb5sfe/pdb
• Group deposition: Exploiting Structural Data for Improved On-Target Prediction in Lead Optimization (G_1002226)
• Descriptor: cAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A, ZINC ION, MAGNESIUM ION, ... (5 entities in total)
• Functional Keywords: phosphodiesterase, pde10, hydrolase, schizophrenia, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 4
• Total formula weight: 159641.27

Authors

Joseph, C.,Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G. (deposition date: 2022-01-21, release date: 2022-10-19, Last modification date: 2024-10-16)

• Primary citation: Gobbi, L.,Benz, J.,Schlatter, D.,Rudolph, M.G.; Crystal Structure of a human phosphodiesterase 10 complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.86 Å)