5SD1

Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1235 (enantiomer)

Summary for 5SD1

• Entry DOI: 10.2210/pdb5sd1/pdb
• Group deposition: DHFR structures, SSGCID (G_1002223)
• Descriptor: Dihydrofolate reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2S)-2-[(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl)oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid, ... (6 entities in total)
• Functional Keywords: mycobacterium tuberculosis, dhfr, nadp, folate, oxidoreductase-oxidoreductase inhibitor complex, structural genomics, seattle structural genomics center for infectious disease, ssgcid, oxidoreductase/oxidoreductase inhibitor
• Biological source: Mycobacterium tuberculosis H37Rv
• Total number of polymer chains: 1
• Total formula weight: 21156.35

Authors

Seattle Structural Genomics Center for Infectious Disease (SSGCID) (deposition date: 2021-12-20, release date: 2022-02-09, Last modification date: 2024-05-22)

• Primary citation: Mayclin, S.J.,Fairman, J.W.,Dranow, D.M.,Conrady, D.G.,Fox III, D.,Lukacs, C.M.,Lorimer, D.D.,Horanyi, P.S.,Edwards, T.E.,Abendroth, J.; Crystal Structure of Dihydrofolate Reductase from Mycobacterium tuberculosis bound to NADP and SDDC Inhibitor SDDC-1235 (enantiomer); to be published,

Experimental method

X-RAY DIFFRACTION (2 Å)