5SCA

Structure of liver pyruvate kinase in complex with anthraquinone derivative 36

Summary for 5SCA

• Entry DOI: 10.2210/pdb5sca/pdb
• Group deposition: ADP-competitive inhibitors of PKL (G_1002224)
• Descriptor: Pyruvate kinase, 1,6-di-O-phosphono-beta-D-fructofuranose, OXALATE ION, ... (7 entities in total)
• Functional Keywords: pyruvate kinase, active site, inhibition, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 8
• Total formula weight: 392401.35

Authors

Lulla, A.,Foller, A.,Nain-Perez, A.,Grotli, M.,Brear, P.,Hyvonen, M. (deposition date: 2021-12-01, release date: 2022-03-16, Last modification date: 2022-03-30)

• Primary citation: Nain-Perez, A.,Foller Fuchtbauer, A.,Haversen, L.,Lulla, A.,Gao, C.,Matic, J.,Monjas, L.,Rodriguez, A.,Brear, P.,Kim, W.,Hyvonen, M.,Boren, J.,Mardinoglu, A.,Uhlen, M.,Grotli, M.; Anthraquinone derivatives as ADP-competitive inhibitors of liver pyruvate kinase.; Eur.J.Med.Chem., 234:114270-114270, 2022; PubMed: 35290845; DOI: 10.1016/j.ejmech.2022.114270

Experimental method

X-RAY DIFFRACTION (1.918 Å)