5SAF

PanDDA analysis group deposition -- Crystal Structure of SARS-CoV-2 NendoU in complex with EN300-321461

Summary for 5SAF

• Entry DOI: 10.2210/pdb5saf/pdb
• Group deposition: PanDDA analysis group deposition (G_1002199)
• Descriptor: Uridylate-specific endoribonuclease, CITRIC ACID, 6,7-dihydro-5H-pyrrolo[2,3-d]pyrimidine, ... (4 entities in total)
• Functional Keywords: sgc - diamond i04-1 fragment screening, pandda, xchemexplorer, nsp15, nendou, sars-cov-2, sars, covid, covid19, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV)
• Total number of polymer chains: 2
• Total formula weight: 78851.60

Authors

Godoy, A.S.,Douangamath, A.,Nakamura, A.M.,Dias, A.,Krojer, T.,Noske, G.D.,Gawiljuk, V.O.,Fernandes, R.S.,Fairhead, M.,Powell, A.,Dunnet, L.,Aimon, A.,Fearon, D.,Brandao-Neto, J.,Skyner, R.,von Delft, F.,Oliva, G. (deposition date: 2021-05-19, release date: 2021-06-09, Last modification date: 2023-05-10)

• Primary citation: Godoy, A.S.,Nakamura, A.M.,Douangamath, A.,Song, Y.,Noske, G.D.,Gawriljuk, V.O.,Fernandes, R.S.,Pereira, H.D.M.,Oliveira, K.I.Z.,Fearon, D.,Dias, A.,Krojer, T.,Fairhead, M.,Powell, A.,Dunnet, L.,Brandao-Neto, J.,Skyner, R.,Chalk, R.,Bajusz, D.,Bege, M.,Borbas, A.,Keseru, G.M.,von Delft, F.,Oliva, G.; Allosteric regulation and crystallographic fragment screening of SARS-CoV-2 NSP15 endoribonuclease.; Nucleic Acids Res., 2023; PubMed: 37115000; DOI: 10.1093/nar/gkad314

Experimental method

X-RAY DIFFRACTION (2.11 Å)