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5RW8

INPP5D PanDDA analysis group deposition -- Crystal Structure of the phosphatase and C2 domains of SHIP1 in complex with Z28290384

Summary for 5RW8
Entry DOI10.2210/pdb5rw8/pdb
Group depositionINPP5D PanDDA analysis group deposition (G_1002180)
DescriptorPhosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1, N-(2-fluorophenyl)-3-methoxybenzamide, DIMETHYL SULFOXIDE, ... (4 entities in total)
Functional Keywordssgc - diamond i04-1 fragment screening, pandda, xchemexplorer, ship1, alzheimers, hydrolase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight53357.22
Authors
Bradshaw, W.J.,Newman, J.A.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Gileadi, O. (deposition date: 2020-10-30, release date: 2020-11-11, Last modification date: 2024-02-14)
Primary citationBradshaw, W.J.,Kennedy, E.C.,Moreira, T.,Smith, L.A.,Chalk, R.,Katis, V.L.,Benesch, J.L.P.,Brennan, P.E.,Murphy, E.J.,Gileadi, O.
Regulation of inositol 5-phosphatase activity by the C2 domain of SHIP1 and SHIP2.
Structure, 2024
Cited by
PubMed: 38309262
DOI: 10.1016/j.str.2024.01.005
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.27 Å)
Structure validation

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