5QJ1
CRYSTAL STRUCTURE OF THE HEPATITIS C VIRUS GENOTYPE 2A STRAIN JFH1 L30S NS5B RNA-DEPENDENT RNA POLYMERASE IN COMPLEX WITH 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide
5QJ1 の概要
エントリーDOI | 10.2210/pdb5qj1/pdb |
Group deposition | NS5B 1b (G_1002055) |
分子名称 | RNA-dependent RNA polymerase, 6-(ethylamino)-2-(4-fluorophenyl)-5-(3-{[1-(5-fluoropyrimidin-2-yl)cyclopropyl]carbamoyl}-4-methoxyphenyl)-N-methyl-1-benzofuran-3-carboxamide, SULFATE ION, ... (6 entities in total) |
機能のキーワード | rdrp structure (fingers, palm, thumb domains), acetylation, apoptosis, atp-binding, capsid protein, cell membrane, cytoplasm, disulfide bond, endoplasmic reticulum, envelope protein, fusion protein, glycoprotein, helicase, host-virus interaction, hydrolase, interferon antiviral system evasion, lipid droplet, lipoprotein, membrane, metal- binding, mitochondrion, multifunctional enzyme, nucleotide- binding, nucleotidyltransferase, nucleus, oncogene, palmitate, phosphoprotein, protease, ribonucleoprotein, rna replication, rna-binding, rna-directed rna polymerase, secreted, serine protease, sh3-binding, thiol protease, transcription, transcription regulation, transferase, transmembrane, ubl conjugation, viral nucleoprotein, virion, zinc, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
由来する生物種 | Hepacivirus C |
タンパク質・核酸の鎖数 | 1 |
化学式量合計 | 66444.67 |
構造登録者 | |
主引用文献 | Yeung, K.S.,Beno, B.R.,Mosure, K.,Zhu, J.,Grant-Young, K.A.,Parcella, K.,Anjanappa, P.,Bora, R.O.,Selvakumar, K.,Wang, Y.K.,Fang, H.,Krause, R.,Rigat, K.,Liu, M.,Lemm, J.,Sheriff, S.,Witmer, M.,Tredup, J.,Jardel, A.,Kish, K.,Parker, D.,Haskell, R.,Santone, K.,Meanwell, N.A.,Soars, M.G.,Roberts, S.B.,Kadow, J.F. Structure-Property Basis for Solving Transporter-Mediated Efflux and Pan-Genotypic Inhibition in HCV NS5B Inhibitors. ACS Med Chem Lett, 9:1217-1222, 2018 Cited by PubMed: 30613329DOI: 10.1021/acsmedchemlett.8b00379 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.17 Å) |
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