5QDM
PanDDA analysis group deposition -- Crystal structure of PTP1B in complex with compound_FMOPL000074a
Summary for 5QDM
| Entry DOI | 10.2210/pdb5qdm/pdb |
| Group deposition | PanDDA analysis group deposition of models with modelled events (e.g. bound ligands) (G_1002043) |
| Descriptor | Tyrosine-protein phosphatase non-receptor type 1, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-[4-(1~{H}-pyrazol-3-yl)phenoxy]pyrimidine, ... (4 entities in total) |
| Functional Keywords | pandda, sgc - diamond i04-1 fragment screening, protein tyrosine phosphatase, ptp, protein tyrosine phosphatase 1b, ptp1b, enzyme, allostery, multiconformer, hydrolase |
| Biological source | Homo sapiens (Human) |
| Total number of polymer chains | 1 |
| Total formula weight | 37705.95 |
| Authors | Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,von Delft, F.,Wells, J.A.,Fraser, J.S. (deposition date: 2018-08-30, release date: 2018-10-10, Last modification date: 2024-03-06) |
| Primary citation | Keedy, D.A.,Hill, Z.B.,Biel, J.T.,Kang, E.,Rettenmaier, T.J.,Brandao-Neto, J.,Pearce, N.M.,von Delft, F.,Wells, J.A.,Fraser, J.S. An expanded allosteric network in PTP1B by multitemperature crystallography, fragment screening, and covalent tethering. Elife, 7:-, 2018 Cited by PubMed: 29877794DOI: 10.7554/eLife.36307 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (2.647 Å) |
Structure validation
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