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5QC6

Crystal structure of human Cathepsin-S with bound ligand

Summary for 5QC6
Entry DOI10.2210/pdb5qc6/pdb
Group depositionLigand binding to Cathepsin S (G_1002040)
DescriptorCathepsin S, (4~{S})-1-[1-[(2~{S})-3-[3-[3-[2-(4-methylpiperidin-1-yl)ethylsulfanyl]-4-(trifluoromethyl)phenyl]-5-methylsulfonyl-6,7-dihydro-4~{H}-pyrazolo[4,3-c]pyridin-1-yl]-2-oxidanyl-propyl]piperidin-4-yl]-4-oxidanyl-pyrrolidin-2-one (3 entities in total)
Functional Keywordsd3r, cathepsin s, ligand docking, hydrolase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight50518.77
Authors
Bembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K. (deposition date: 2017-08-04, release date: 2017-12-20, Last modification date: 2021-11-17)
Primary citationBembenek, S.D.,Ameriks, M.K.,Mirzadegan, T.,Yang, H.,Shao, C.,Burley, S.K.
Crystal structure of human Cathepsin-S with bound ligand
To be published,
Experimental method
X-RAY DIFFRACTION (2.1 Å)
Structure validation

217705

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