5P9H
BTK1 COCRYSTALLIZED WITH RN983
Summary for 5P9H
Entry DOI | 10.2210/pdb5p9h/pdb |
Group deposition | Crystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011) |
Descriptor | Tyrosine-protein kinase BTK, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one (3 entities in total) |
Functional Keywords | protein kinase, transferase |
Biological source | Homo sapiens (Human) |
Cellular location | Cytoplasm: Q06187 |
Total number of polymer chains | 1 |
Total formula weight | 32950.78 |
Authors | Gardberg, A.S. (deposition date: 2016-09-20, release date: 2017-05-24, Last modification date: 2024-05-22) |
Primary citation | Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L. Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling. Mol. Pharmacol., 91:208-219, 2017 Cited by PubMed: 28062735DOI: 10.1124/mol.116.107037 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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