5P9H

BTK1 COCRYSTALLIZED WITH RN983

Summary for 5P9H

Group depositionCrystal structures of Tyrosine-protein kinase BTK in complex with inhibitors (G_1002011)
DescriptorTyrosine-protein kinase BTK, 6-~{tert}-butyl-8-fluoranyl-2-[3-(hydroxymethyl)-4-[1-methyl-5-[[5-(1-methylpiperidin-4-yl)pyridin-2-yl]amino]-6-oxidanylidene-pyridazin-3-yl]pyridin-2-yl]phthalazin-1-one (3 entities in total)
Functional Keywordsprotein kinase, transferase
Biological sourceHomo sapiens (Human)
Cellular locationCytoplasm Q06187
Total number of polymer chains1
Total molecular weight32950.78
Authors
Gardberg, A.S. (deposition date: 2016-09-20, release date: 2017-05-24, Last modification date: 2018-02-21)
Primary citation
Bender, A.T.,Gardberg, A.,Pereira, A.,Johnson, T.,Wu, Y.,Grenningloh, R.,Head, J.,Morandi, F.,Haselmayer, P.,Liu-Bujalski, L.
Ability of Bruton's Tyrosine Kinase Inhibitors to Sequester Y551 and Prevent Phosphorylation Determines Potency for Inhibition of Fc Receptor but not B-Cell Receptor Signaling.
Mol. Pharmacol., 91:208-219, 2017
PubMed: 28062735 (PDB entries with the same primary citation)
DOI: 10.1124/mol.116.107037
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.95 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.329302.7%20.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 5p9h
no rotation
Molmil generated image of 5p9h
rotated about x axis by 90°
Molmil generated image of 5p9h
rotated about y axis by 90°
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