5P93
humanized rat catechol O-methyltransferase in complex with single conformation of 5-(4-fluorophenyl)-2,3-dihydroxy-N-[2-(3-pyridin-4-yl-1H-1,2,4-triazol-5-yl)ethyl]benzamide at 1.24A
Summary for 5P93
Entry DOI | 10.2210/pdb5p93/pdb |
Group deposition | Crystal Structure of COMT complex (G_1002009) |
Descriptor | Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total) |
Functional Keywords | methyltransferase, neurotransmitter degradation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Rattus norvegicus (Rat) |
Cellular location | Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734 |
Total number of polymer chains | 1 |
Total formula weight | 25512.30 |
Authors | Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-29, release date: 2017-08-30, Last modification date: 2024-04-03) |
Primary citation | Lerner, C.,Rudolph, M.G. Crystal Structure of a COMT complex To be published, |
Experimental method | X-RAY DIFFRACTION (1.24 Å) |
Structure validation
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