5P91

humanized rat catechol O-methyltransferase in complex with 5-(4-fluorophenyl)-2,3-dihydroxy-N-[2-[5-(2-methylpyridin-4-yl)-4H-1,2,4-triazol-3-yl]ethyl]benzamide at 1.20A

Summary for 5P91

• Entry DOI: 10.2210/pdb5p91/pdb
• Group deposition: Crystal Structure of COMT complex (G_1002009)
• Descriptor: Catechol O-methyltransferase, MAGNESIUM ION, CHLORIDE ION, ... (7 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, transferase, transferase-transferase inhibitor complex, transferase/transferase inhibitor
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 1
• Total formula weight: 25526.33

Authors

Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-29, release date: 2017-08-30, Last modification date: 2024-04-03)

• Primary citation: Lerner, C.,Rudolph, M.G.; Crystal Structure of a COMT complex; To be published,

Experimental method

X-RAY DIFFRACTION (1.2 Å)