5P8W

Crystal Structure of COMT in complex with [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine

Summary for 5P8W

• Entry DOI: 10.2210/pdb5p8w/pdb
• Group deposition: Crystal Structure of COMT complex (G_1002007)
• Descriptor: Catechol O-methyltransferase, 2,3-DIHYDROXY-1,4-DITHIOBUTANE, [5-(2,4-dimethyl-1,3-thiazol-5-yl)-1H-pyrazol-3-yl]methanamine, ... (6 entities in total)
• Functional Keywords: methyltransferase, neurotransmitter degradation, transferase
• Biological source: Rattus norvegicus (Rat)
• Cellular location: Isoform 2: Cytoplasm. Isoform 1: Cell membrane; Single-pass type II membrane protein; Extracellular side: P22734
• Total number of polymer chains: 3
• Total formula weight: 75423.62

Authors

Ehler, A.,Lerner, C.,Rudolph, M.G. (deposition date: 2016-08-25, release date: 2016-09-07, Last modification date: 2024-10-30)

• Primary citation: Lerner, C.,Rudolph, M.G.; Crystal Structure of COMT complex; To be published,

Experimental method

X-RAY DIFFRACTION (2.03 Å)