5OY6

Crystal structure of the ACVR1 (ALK2) kinase in complex with cyclical inhibitor OD36.

Summary for 5OY6

• Entry DOI: 10.2210/pdb5oy6/pdb
• Descriptor: Activin receptor type-1, cyclical inhibitor OD36, 1,2-ETHANEDIOL, ... (4 entities in total)
• Functional Keywords: kinase, alk2, receptor, bmp, structural genomics, structural genomics consortium, sgc, signaling protein
• Biological source: Homo sapiens (Human)
• Cellular location: Membrane; Single-pass type I membrane protein: Q04771
• Total number of polymer chains: 4
• Total formula weight: 139597.74

Authors

Williams, E.P.,Pinkas, D.M.,Krojer, T.,Kupinska, K.,Mahajan, P.,Burgess-Brown, N.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.N. (deposition date: 2017-09-07, release date: 2017-09-27, Last modification date: 2024-01-17)

• Primary citation: Sanchez-Duffhues, G.,Orlova, V.,Benderitter, P.,Williams, E.P.,Garcia de Vinuesa, A.,Caradec, J.,van Wijhe, M.,de Boer, H.,Goumans, M.J.,Eeckhoff, M.,Morales Piga, A.,Bachiller, J.,Koolwijk, P.,Bullock, A.,Hoflack, J.,ten Dijke, P.; Establishment and characterization of endothelial colony forming cells as a surrogate model for Fibrodysplasia Ossificans Progressiva; To Be Published,

Experimental method

X-RAY DIFFRACTION (2.56 Å)