5OWT
Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione
Summary for 5OWT
Entry DOI | 10.2210/pdb5owt/pdb |
Descriptor | Tankyrase-2, SULFATE ION, (5S)-5-methyl-5-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione, ... (5 entities in total) |
Functional Keywords | tankyrase, inhibitor, artd6, parp5b, adp-ribosyltransferase, transferase |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 55783.26 |
Authors | Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (deposition date: 2017-09-04, release date: 2018-05-02, Last modification date: 2024-01-17) |
Primary citation | Nkizinkiko, Y.,Desantis, J.,Koivunen, J.,Haikarainen, T.,Murthy, S.,Sancineto, L.,Massari, S.,Ianni, F.,Obaji, E.,Loza, M.I.,Pihlajaniemi, T.,Brea, J.,Tabarrini, O.,Lehtio, L. 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors. Sci Rep, 8:1680-1680, 2018 Cited by PubMed: 29374194DOI: 10.1038/s41598-018-19872-3 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.2 Å) |
Structure validation
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