5OWT

Crystal structure of TNKS2 in complex with (5S)-5-methyl-5-[4-(4-oxo-3,4-dihydroquinazolin-2-yl)phenyl]imidazolidine-2,4-dione

5OWT の概要

• エントリーDOI: 10.2210/pdb5owt/pdb
• 分子名称: Tankyrase-2, SULFATE ION, (5S)-5-methyl-5-[4-(4-oxidanylidene-3H-quinazolin-2-yl)phenyl]imidazolidine-2,4-dione, ... (5 entities in total)
• 機能のキーワード: tankyrase, inhibitor, artd6, parp5b, adp-ribosyltransferase, transferase
• 由来する生物種: Homo sapiens (Human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 55783.26

構造登録者

Nkizinkiko, Y.,Haikarainen, T.,Lehtio, L. (登録日: 2017-09-04, 公開日: 2018-05-02, 最終更新日: 2024-01-17)

• 主引用文献: Nkizinkiko, Y.,Desantis, J.,Koivunen, J.,Haikarainen, T.,Murthy, S.,Sancineto, L.,Massari, S.,Ianni, F.,Obaji, E.,Loza, M.I.,Pihlajaniemi, T.,Brea, J.,Tabarrini, O.,Lehtio, L.; 2-Phenylquinazolinones as dual-activity tankyrase-kinase inhibitors.; Sci Rep, 8:1680-1680, 2018; PubMed: 29374194; DOI: 10.1038/s41598-018-19872-3

実験手法

X-RAY DIFFRACTION (2.2 Å)