5OWH

High salt structure of human protein kinase CK2alpha in complex with 3-aminopropyl-4,5,6,7-tetrabromobenzimidazol

Summary for 5OWH

Entry DOI	10.2210/pdb5owh/pdb
Descriptor	Casein kinase II subunit alpha, 3-[4,5,6,7-tetrakis(bromanyl)benzimidazol-1-yl]propan-1-amine, CHLORIDE ION, ... (4 entities in total)
Functional Keywords	protein kinase ck2 casein kinase 2 atp-competitive inhibitor 3-aminopropyl-4, 5, 6, 7-tetrabromobenzimidazol, transferase
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	40593.01
Authors	Niefind, K.,Bretner, M.,Chojnacki, C. (deposition date: 2017-09-01, release date: 2018-07-25, Last modification date: 2024-01-17)
Primary citation	Chojnacki, K.,Winska, P.,Wielechowska, M.,Lukowska-Chojnacka, E.,Tolzer, C.,Niefind, K.,Bretner, M. Biological properties and structural study of new aminoalkyl derivatives of benzimidazole and benzotriazole, dual inhibitors of CK2 and PIM1 kinases. Bioorg. Chem., 80:266-275, 2018 Cited by PubMed: 29966873 DOI: 10.1016/j.bioorg.2018.06.022 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation