5OW8

Indole-2 carboxamides as selective secreted phospholipase A2 type X (sPLA2-X) inhibitors

Summary for 5OW8

Entry DOI	10.2210/pdb5ow8/pdb
Descriptor	Group 10 secretory phospholipase A2, CALCIUM ION, DIMETHYL SULFOXIDE, ... (7 entities in total)
Functional Keywords	inhibitor, secreted, phospholipase, lipid binding protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	2
Total formula weight	29275.24
Authors	Sandmark, J.S.,Roth, R.G.,Knerr, L.,Bodin, C.,Pettersen, D. (deposition date: 2017-08-31, release date: 2018-08-01, Last modification date: 2021-05-05)
Primary citation	Knerr, L.,Giordanetto, F.,Nordberg, P.,Pettersen, D.,Selmi, N.,Beisel, H.G.,de la Motte, H.,Olsson, T.,Perkins, T.D.J.,Herslof, M.,Mansson, A.,Dahlstrom, M.,Starke, I.,Broddefalk, J.,Saarinen, G.,Klingegard, F.,Hurt-Camejo, E.,Rosengren, B.,Brengdahl, J.,Jansen, F.,Rohman, M.,Sandmark, J.,Hallberg, K.,Akerud, T.,Roth, R.G.,Ahlqvist, M. Discovery of a Series of Indole-2 Carboxamides as Selective Secreted Phospholipase A2Type X (sPLA2-X) Inhibitors. Acs Med.Chem.Lett., 9:594-599, 2018 Cited by PubMed: 30034585 DOI: 10.1021/acsmedchemlett.7b00505 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation