5OVB
Crystal structure of human BRD4(1) bromodomain in complex with DR46
Summary for 5OVB
Entry DOI | 10.2210/pdb5ovb/pdb |
Descriptor | Bromodomain-containing protein 4, ~{N}-[3-(5-ethanoyl-2-ethoxy-phenyl)-5-(1-methylpyrazol-3-yl)phenyl]furan-2-carboxamide (3 entities in total) |
Functional Keywords | brd4 bromodomain 1(brp4(1)), inhibitor, dna binding protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 31057.70 |
Authors | Zhu, J.,Caflisch, A. (deposition date: 2017-08-28, release date: 2018-10-10, Last modification date: 2024-01-17) |
Primary citation | Batiste, L.,Unzue, A.,Dolbois, A.,Hassler, F.,Wang, X.,Deerain, N.,Zhu, J.,Spiliotopoulos, D.,Nevado, C.,Caflisch, A. Chemical Space Expansion of Bromodomain Ligands Guided by in Silico Virtual Couplings (AutoCouple). Acs Cent.Sci., 4:180-188, 2018 Cited by PubMed: 29532017DOI: 10.1021/acscentsci.7b00401 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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