5OV2

2'F-ANA-G modified quadruplex with a flipped tetrad

5OV2 の概要

• エントリーDOI: 10.2210/pdb5ov2/pdb
• 関連するPDBエントリー: 2LOD 5MCR
• NMR情報: BMRB: 34174
• 分子名称: artificial quadruplex with propeller, diagonal, and lateral loop (1 entity in total)
• 機能のキーワード: g-quadruplex, dna, 2'f-ana
• 由来する生物種: synthetic construct
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 7026.46

構造登録者

Dickerhoff, J.,Weisz, K. (登録日: 2017-08-27, 公開日: 2017-10-18, 最終更新日: 2024-05-15)

主引用文献

Dickerhoff, J.,Weisz, K.
Nonconventional C-HF Hydrogen Bonds Support a Tetrad Flip in Modified G-Quadruplexes.
J Phys Chem Lett, 8:5148-5152, 2017

PubMed Abstract: A G-quadruplex adopting a (3 + 1)-hybrid structure was substituted at its 5'-tetrad by 2'-deoxy-2'-fluoro-arabinoguanosine (araG) analogs. Incorporation of anti-favoring araG at syn-positions of the 5'-outer tetrad induced a reversal of the tetrad polarity without noticeably compromising the quadruplex stability. This conformational change is shown to be promoted by nonconventional C-H···F hydrogen bonds acting within the anti-araG residues.

PubMed: 28976755
DOI: 10.1021/acs.jpclett.7b02428

実験手法

SOLUTION NMR