2LOD

Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops

Summary for 2LOD

• Entry DOI: 10.2210/pdb2lod/pdb
• NMR Information: BMRB: 18209
• Descriptor: DNA (5'-D(*GP*GP*GP*AP*TP*GP*GP*GP*AP*CP*AP*CP*AP*GP*GP*GP*GP*AP*CP*GP*GP*G)-3') (1 entity in total)
• Functional Keywords: g-quadruplex, dna, loops
• Total number of polymer chains: 1
• Total formula weight: 6972.49

Authors

Marusic, M.,Sket, P.,Bauer, L.,Viglasky, V.,Plavec, J. (deposition date: 2012-01-23, release date: 2012-05-30, Last modification date: 2024-05-01)

Primary citation

Marusic, M.,Sket, P.,Bauer, L.,Viglasky, V.,Plavec, J.
Solution-state structure of an intramolecular G-quadruplex with propeller, diagonal and edgewise loops.
Nucleic Acids Res., 40:6946-6956, 2012

PubMed Abstract: We herein report on the formation and high-resolution NMR solution-state structure determination of a G-quadruplex adopted by d[G(3)ATG(3)ACACAG(4)ACG(3)] comprised of four G-tracts with the third one consisting of four guanines that are intervened with non-G streches of different lengths. A single intramolecular antiparallel (3+1) G-quadruplex exhibits three stacked G-quartets connected with propeller, diagonal and edgewise loops of different lengths. The propeller and edgewise loops are well structured, whereas the longer diagonal loop is more flexible. To the best of our knowledge, this is the first high-resolution G-quadruplex structure where all of the three main loop types are present.

PubMed: 22532609
DOI: 10.1093/nar/gks329

Experimental method

SOLUTION NMR